Unblocks your nose fast Lasts up to 10 hours Non-drowsy Metered spray Xylometazoline hydrochloride. How does this product help? Sudafed Blocked Nose Spray with Xylometazoline hydrochloride, works in minutes to help clear blocked noses and relieve sinus pressure caused by colds and hayfever. The metered spray gives an exact dose that lasts for up to 10 hours. Sudafed is a registered trade mark.