Thiamin (vitamin B-1) is intimately involved in many aspects of nerve health and function. The active co-enzyme (TPP), is necessary for energy production and is essential for the formation of acetylcholine, a major neurotransmitter. Magnesium plays a role in neuromuscular transmission and activity, promoting muscle relaxation. A highly processed ""junk food"" diet, excessive alcohol intake, and exhaustive exercise may increase the need for. ThiaMind .