Biofreeze Spray has a slightly different formulation to the Biofreeze Gel and contains natural menthol, MSM, Ilex and a new blend of botanical ingredients, Arnica, Calendula, Chamomile, Echinacea, Juniper Berry, and White Tea. The Biofreeze Spray formula provides longer lasting pain relief for those hard-to-reach areas, such as the middle back and lower extremities. Biofreeze works using Cryotherapy, a process which dramatically cools the affected area to relieve pain in two ways. Firstly it reduces the blood flow to the area and secondly Biofreeze Gel reduces the ability of the nerves to conduct painful stimulation to the brain. The unique Biofreeze formulation contains Ilex, a herb extracted from the South American Holly shrub, traditionally used by the Paraguay Indians. Ilex helps the gel to powerfully penetrate the affected areas. Biofreeze Pain Relieving Gel can give fast acting pain relief from muscle and joint complaints, Arthritis, Sore Muscles and Joints and Backache.