What is Venalex? in other countries Detralex Venalex is a nutritional supplement which contains MPFF - Micronized Purified Flavonoid Fraction - a combination od diosmin (450 mg) and hesperidin (50 mg) in ratio 9:1. 1 capsule of Venalex contains: diosmin - 450 mg hesperidin - 50 mg How to dose Venalex? Adults: 2 capsules per day Do not exceed the recommended daily dose. Nutritional supplement cannot substitute for a healthy, balanced diet. Available packages of Venalex: Venalex - package containing 60 capsules Chronic Venous Insufficiency CVI - Chronic Venous Insufficiency Chronic venous insufficiency is a syndrome associated with venous blood stasis in veins, reflux (return venous flow) and occlusion of veins. These symptoms leads to abnormal return of venous blood from limbs to heart. First symptoms of CVI are little swellings occuring mainly in late hours, discoloration and appearence of small veins on the skin. With progress of disease, patient can suffer from "leg heaviness", resolving after short rest with legs elevated over the level of heart. Further progress leads to development of varicose veins, edema, recurrent inflammation of the veins, bleeding from varicose veins and trophic skin changes. MPFF - Micronized Purified Flavonoid Fraction MPFF - is a shortage from Micronized Purified Flavonoid Fraction which is a combination of diosmin with hesperidin in ratio 9:1. Diosmin Diosmin is a molecule belonging to flavonoids. It is a natural substance extracted from citrus fruits, mainly from Citrus aurantium. Diosmin increases venous tone through increasing in sensitivity to Ca2+ preventing blood stasis in venous system, mainly in lower limbs. Diosmin also acts antiedematously by improving lymphatic drainage and lymph flow. Hesperidin Hesperidin in also one of flavonoids and similarily to diosmin comes from the nature and is extracted from citrus fruits. Hesperidin is a strong anti-inflammatory molecule.